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With significantly increased progression-free survival (PFS) rates and positive radiological responses, Bev was FDA-approved to be used as a second-line treatment or in combination with first-line treatments for recurrent GBM (156, 160, 176, 177)

A key clinical challenge is the lack of a standardized optimal cut-off value, which ranges from 2.0 to 5.0, limiting direct comparisons across different studies and institutions (93)

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In conclusion, oxidative and ER stress are critical factors in mycotoxins' ability to cause apoptosis