l carnitine mode of action

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Moreover, Dysbiosis can trigger an inflammatory response, characterized by the release of pro-inflammatory cytokines such as TNF- , IL-6, and IFN- , these cytokines can directly affect the expression and distribution of TJ proteins (38)

This implies that, at physiological pH, these residues will be predominantly found as thiolates, which are much stronger nucleophiles than thiol groups

In mammalian cells, DNA double-strand breaks are primarily repaired through NHEJ, an error-prone pathway that generates unpredictable insertions or deletions, rather than through the desired HDR pathway [238]