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doi: 10.3390/ijms19061804 57

There are use patches that transfer B12 through the skin, yet these patches are limited by how much B12 can be naturally absorbed by the skin and transferred into the blood stream

[14] The identity of the receptor or receptors that mediate these E-peptide effects remains, as of the current literature, unresolved and, as the in-vivo work discussed below shows, the claim of full IGF-1R independence is itself contested by studies in which E-peptide-driven hypertrophy did require the receptor