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B) is the ROS sensitive transcription factor and plays important role in the inflammatory gene expression and pro-inflammatory gene expression like monocyte chemotactic protein-1 (MCP-1) andinterleukin-6

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183,189,190 Senescent fibroblasts secrete matrix metalloproteinase 3, which affects the morphological and functional differentiation of mammary epithelial cells, ultimately relaxing restrictions on cell migration/invasion