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More serious complications encompass lipid profile alterations, acute pancreatitis, cardiomyopathy, metabolic disturbances, including hyperuricemia, hyponatremia, hypoproteinemia, persistent acidosis, and hypomagnesemia, and bone and mineral metabolism issues such as hypercalciuria, hypocitraturia, kidney stone formation, and urine acidification

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ITC characterizes the thermodynamic properties of a ligand binding reaction, and thus allows a quantitative measurement of both binding affinity and stoichiometry

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