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In the previous eras, it took some time for anti-doping testing and capabilities to catch up with the trends in mainstream substance development

L-arginine-rats, L-NAME-rats, L-NAME+L-arginine-rats Alone, L-arginine prolonged bleeding time (rats with amputation only) and increased the amount of bleeding (heparin-rats, warfarin-rats) while L-NAME reduced bleeding time (rats with amputation only)