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10-year acceleration of aging (Akarsu et al

[DOI] [PubMed] [Google Scholar] 124.Li S., Ke Z., Peng X., Fan P., Chao J., Wu P., Xiao P., Zhou Y

Amorphous solid dispersions, while improving solubility, have a natural tendency to transform into a more stable crystalline form over time, which can lead to a loss of the bioavailability benefit ( 8.5.5.4 Toxicity of excipients and carriers Some excipients or carrier materials used in these formulations, especially surfactants in SMEDDS or certain polymers in nanoparticles, might have inherent toxicity concerns, particularly with long-term use or at high doses

Another major risk of these medications is the induction of autoimmune disease (marked by anti-DNA antibodies) in up to 1/3 of users