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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Gopinath VS, Rao M, Shivahare R, Vishwakarma P, Ghose S, Pradhan A, Hindupur R, Sarma KD, Gupta S, Puri SK, Launay D, Martin D

Nevertheless, the lack of glucose intolerance in FIRKO mice suggested that insulin resistance in tissues other than WAT is involved in developing hyperglycemia in Insr P1195L/ +/HFD mice

Some studies show a small increase in resting metabolic rate, possibly mediated by improved insulin sensitivity and reduced lipotoxicity in tissues

The work supports the broader HGF/c-Met mechanism beyond the hippocampal cognitive context, and the zebrafish protection model has been further studied in subsequent work in mammalian systems