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But theres a problem, says Dr Michael Sagner, a Kings College clinical adviser and expert in NAD+

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We found robust neurodegenerative features in cognitively impaired aged degus, including hippocampal neuronal loss, altered parvalbumin and perineuronal net staining in the cortex, and increased c-Fos neuronal activation in the cortex that is consistent with the neural circuit hyperactivity that are commonly reported in human Alzheimers Disease patients, explained corresponding author Xiangmin Xu, PhD, professor and Chancellors Fellow of anatomy and neurobiology in the UCI School of Medicine, and director of the Center for Neural Circuit Mapping

Weight reduction: Clinical trials report substantial bodyweight loss (up to ~11 kg more than GLP1 RA comparators over 26 weeks at higher doses) [3] [4]