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10 NO and its by-products, such as nitrate (NO3-), nitrite (NO2-), peroxynitrite (ONOO-), and 3-nitrotyrosine are called reactive nitrogen species (RNS)

doi: 10.1126/science.aay4106

Free Radic Biol Med 94:8898

Going all the way back to 1817, when James Parkinson first described the disease in the scientific literature, its been a clinically defined condition