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CCL11 is highly expressed in SMC-rich area of the atherosclerosis plaque and injured arteries, suggesting that it plays an important role in regulating SMC migration [40, 41]

Pathophysiology of gastroesophageal reflux disease and oesophageal mucosal injury At the oesophagusstomach junction lies the circular smooth muscle structure called the LES (Reference Hershcovici, Mashimo and Fass15)

Cryo-EM data were acquired on a 300 kV Titan Krios electron microscope (Thermo Fisher Scientific) equipped with a K3 Summit direct electron detector (Gatan) mounted after a quantum energy filter set to a slit width of 20 eV

18,19 While PDE-5 inhibitors have revolutionized the management of ED, the remainder of this review will focus on alternative treatment options and potential treatment strategies in the setting of failed PDE-5 inhibitor therapy or contraindications