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GPx8 has been shown to sustain the invasiveness of breast cancer cells via the IL-6/STAT3 signaling pathway (Khatib et al

This decline creates several problems: Low NAD+ leads to reduced DNA repair capacity and more DNA damage Decreased NAD+ hurts mitochondrial fatty acid -oxidation and oxidative phosphorylation NAD+ depletion affects all hallmarks of aging The good news is that restoring NAD+ has shown great results in preclinical studies