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A dose-limiting toxicity (DLT) of Grade 3 dermatitis acneiform occurred at the 8 mg/kg dose level

Lactate interacts with Akt proteins, inducing cellular senescence and oxidative stress by modulating the Akt/p21/p27/cyclin D1 and Akt/Nrf2/HO-1 signaling pathways (Zhang et al., 2024a)