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Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a novel and effective solution, having initially been approved and marketed for glycemic control in type 2 diabetes

Among the various PTMs of p53, acetylation has the greatest effects on p53-mediated ferroptosis during tumorigenesis

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As a potent selective NNMT inhibitor precisely targeting the substrate binding site (IC50 for human NNMT = 1.2 M), 5-amino-1mq liquid specifically blocks this catalytic reaction, leading to marked intracellular nicotinamide accumulation and distinctly elevated NAD+ levels via the conserved NAD+ salvage pathway