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In humans, at least 11 functional isoforms of MTs are known, divided into four classes (MT-1 to MT-4), all of which contain twenty conserved cysteine residues that give them the ability to coordinate seven zinc ions (188, 189)

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Iron, an essential trace element for the human body, is involved in numerous physiological functions such as erythropoiesis, energy metabolism, muscle function and cell cycle regulation (19)

This work was supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases Grants [R01 DK 070195], [R01 DK102142], and [R01 DK125465], the National Institute of General Medicine Grants [P20 GM103549] and [P30 GM118247]