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At the same time, the reduction of MDHA to AsA utilizes nicotinamide adenine dinucleotide phosphate (NADPH) as an electron donor giving up its electron to be converted into NADP+

Consistent with this, use of a reducing source such as -mercaptoethanol allows reversal of xCT-KO phenotype, as it has been reported couple decades ago by Bannai's group ( in vivo can explain the discrepancy with in vitro phenotype

Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments

Furthermore, combination therapies involving ferroptosis induction hold potential to enhance the efficacy of conventional treatments (such as radiotherapy and immunotherapy), while preventing tumor recurrence [19, 21]