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Emerging lines of evidence indicate that E3 exerts a critical regulatory function in oxidative stress homeostasis, primarily through the transcriptional upregulation of pivotal antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx)

140 In this review, we discussed the sources of ROS and how ROS regulate macrophage polarization states

Activation of those genes, in turn, has been shown to extend the lifespan in a wide variety of organisms and to reduce the incidence of age-related diseases, such as diabetes, cancer, immune deficiencies, and cardiovascular disorders (Bordone and Guarente 2005)

FOS is found in onions, leeks, chicory, Jerusalem artichokes, and burdock root