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In this model, reduced phosphorylation of Drp1 and altered proteolytic processing of Opa1 led to increased mitochondrial fission, suggesting that increased lipid uptake, as typically observed in diabetic hearts, may trigger mitochondrial fragmentation and thus mitochondrial dysfunction and ROS [45]

Stein, et al

When ketones cover most of the brains energy demands, the remaining glucose can be more efficiently utilized for other purposes, such as the synthesis of alanine and glutamate, glycogenesis, and antioxidant protection [20]

This state can lead to low-level, persistent inflammation, which is closely linked to weight gain and difficulty losing weight