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When patients with the most severe liver disease were excluded, those who received SAMe were significantly less likely to die or require a liver transplant within the next 2 years than were patients who had received an inactive substance (i.e., a placebo)

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VanderWeele DJ, Zhou R, Rudin CM (2004) Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin

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