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doi: 10.1016/j.bbadis.2005.04.002 214 DelageBFennellDANicholsonLMcNeishILemoineNRCrookTet al

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On the one hand, the chemical reactivity of penicillins is related to the electrophilic properties of the -lactam carbonyl, which is associated with the high tension within the -lactam ring fused to the thiazolidine ring ( The existence of interactions between thiols and -lactam antibiotics, both in vitro and in vivo , has long been known