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Description

Our aim is not to produce a list of defective pathways but to identify common patterns/pathways which may underpin a common etiology in these three conditions

Ethics statement The studies involving humans were approved by Mayo Clinic Center for Regenerative Biotherapeutics Biotrust Oversight Group Committee (Approval Number: IRB # 14001464)

What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation