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FDA review material for tesamorelin noted that loss of VAT benefit after discontinuation was observed by the earliest measured time point after stopping in extension data what researchers commonly describe as tesamorelin VAT rebound after discontinuation

If no protocol produces meaningful improvement, it is time for medical reassessment, as the herniation may require a different intervention entirely

Patients in remission at D2 ( n = 11, = 2.9 0.25) presented a smaller number of previous unsuccessful antidepressant treatments than patients that did not achieve remission ( n = 17, = 4.5 0.43) (MannWhitney: U = 33, p = 0.003)