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[PMC free article: PMC6402807] [PubMed: 30595509] [CrossRef] 4

The major pathological hallmarks of PD are represented by the progressive loss of dopamine(DA)-ergic neurons in the substantia nigra (SN) of the central nervous system (CNS) associated with cytoplasmic inclusions termed as Lewy bodies and Lewy neurites (Spillantini et al., 1997)