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Guerra-De-Blas et al., 2019)

78 Perhaps due to the attention paid to APAP-induced acute liver failure, survival rates of 60% are touted as decent when compared to DILI from other substances

In the metabolism of aromatic amines, N-hydroxy aromatic amine metabolites generated in the liver enter the bladder via urine and are further acetylated by NAT1 in the bladder epithelial cells, resulting in the production of highly reactive intermediates