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Another miRNA shown to regulate Nrf2 is miR-34, able not only to target NFE2L2 but also downstream genes involved in cellular response to OS, such as microsomal glutathione S-transferase 1 ( Mgst1 ) and Sirtuin 1 ( Sirt1 ) genes in rat liver during aging [226]

Choosing the Right Format The Route Question The published preclinical work used intraperitoneal injection in mice a route that approximates IV systemic exposure and is not directly available to humans