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(PubMed) Teikari JM, Rautalahti M, Haukka J, et al

At the molecular level, these changes are principally determined by hypoxia-inducible factor (HIF)mediated reshaping of the transcriptional profile, which depends on the extent, duration, and severity of hypoxia and by unfolded protein response (UPR)modified translational program activated in conditions of severe hypoxia/anoxia [4, 5]

This is likely because exercise increases hormones like progesterone and dopamine that diminish pain

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