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It was demonstrated that PIO could decrease infarct volume and improve the neurological score of transient MCAO mice (Jin et al

Moreover, these ion channels are key regulators of cellular electrical excitability, and their dysfunction correlates with many neurological and cardiovascular manifestations associated with HHcy

The hepatotoxicity of chloroform was reported to be due to phosphogene-mediated cellular glutathione depletion or increased amounts of covalent binding to hepatocellular macromolecules [195,196]