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Among these, disorientation was the most prevalent, followed by clumping and micronuclei, while bridges and binucleate cells were least frequent

In HCC patients, canonical TAM subsets (e.g., SPP1 + TAMs) promote tumor progression through the secretion of factors including macrophage migration inhibitory factor (MIF) and secreted phosphoprotein 1 (SPP1/osteopontin)