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72 Acute fasting and pyruvate deprivation in vivo and in vitro increase glycolytic gene and protein expression in the ovaries, decrease AMPK activity, and enhance mTOR activation, which in turn leads to elevated phosphorylation of downstream proteins like Akt and FOXO3a, promoting primordial follicle activation

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Adverse events were rare in both groups, apart from the incidence of serious hypoglycemia in the lorcaserin group in those with diabetes managed using insulin or sulfonylureas (50, 51)

therefore, GSH deprivation and GPX4 inactivation lead to ferroptosis