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Nature 431 , 9971002, (2004)

Preparation: The treatment area is sanitized, and necessary precautions are taken

Aberrant hypermethylation of promoter regions results in gene silencing, either by preventing transcription factor binding or by facilitating the recruitment of repressor complexes, whereas hypomethylation may inappropriately activate normally silenced genes, thereby promoting genomic instability and dysregulated gene expression [110]

The autophagic machinery helps regulate immune responses at multiple levels - from bacterial clearance to immune cell activation and inflammatory mediator production (343)