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The well-known NAC (N-Acetyl cysteine) has a bioavailability of about 6% while NACET has a much higher bioavailability of 80%

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While BIO89-100 has been reported to be a balanced agonist of FGF21s receptors in vitro , the smaller magnitude of effect on adiponectin compared to efruxifermin suggest that BIO89-100 may not have maximally stimulated FGFR1c signaling in adipose tissue at the doses tested in humans ( Figure 3B )