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The blood flow dynamics simulation was performed using a transient pressure solver with the same boundary conditions and simulation parameters as described previously in our publication of a virtual scalable model of APAP hepatotoxicity prediction ( 2.2.3 APAP metabolism and hepatocyte cellular injury mathematical model (ODE) The cellular injury mathematical model for APAP metabolism, cellular injury, and toxicity prediction serves as an extension of our prior model, thereby more accurately depicting the effects of metabolic zonation of hepatocytes (Figure 2)