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Currently, GnRH agonists are approved by FDA to be used in the preoperative treatment of UF

Although this concept offers a tenable mechanism by which functional and molecular recovery is seen in response to an acute cholinergic challenge, it does not serve as proof that the chronic modulation of these same systems would act to arrest the progressive proteinopathic cascade of AD

However, this inhibition can be counteracted by Smac mimetics which then trigger the activation of the necroptotic death pathway in Burkitts lymphoma cell lines (Koch et al., 2021)