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Furthermore, histochemical analysis of the aortic root using hematoxylin and eosin (H&E) staining revealed that plaques in the PBS group were predominantly characterized by acellular, lipid-rich necrotic cores

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Furthermore, the progression of DKD is strongly associated with pyroptosis-induced inflammation and cellular damage, which exacerbate renal fibrosis, glomerular sclerosis and tubular injury (122)