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[DOI] [PMC free article] [PubMed] [Google Scholar] 248.Wu TY, et al

The solid oral pharmaceutical composition according to any one of claims 1 to 12, wherein the solid oral pharmaceutical composition has a dissolution profile, as determined by the dissolution method according to USP, with less than 5% of the GLP-1 receptor agonist released within 2 hours in simulated gastric fluid, followed by dissolution in simulated intestinal fluid at pH between 6 and 6.5 with a lag time of at least 1 hour, whereby not more than 10% of the GLP-1 receptor agonist is released within the lag time, and whereby after the lag time more than 75% of the GLP-1 receptor agonist is released in simulated intestinal fluid at pH between 6 and 6.5 within 1 hour

[PMC free article: PMC3743250] [PubMed: 23520163] 753

Linlin M, Yuheng L, Wenli P, Jingxin G, Tian Y, Yu Z, Haibing H, Tang X