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Considering that current anti-inflammatory therapy (steroids and immunosuppressant drugs) remains unsatisfactory due to substantial side effects and uncontrolled relapses (349), understand the interaction between gut microbiota and IEB, particularly at the early subclinical phase of inflammatory disease, could be used to identify novel therapeutic approaches in chronic intestinal inflammation

These cells, which are found in significant concentration within superficial veins (see Chapter 2), have a large number of functions, including the synthesis of collagen, elastin, and proteoglycans

SP and HK-1 generated from macrophages, bronchial cells and mast cells cause degranulation of human mast cells via MRGPRX2, Mas-related G protein-coupled receptor-X2, which is upregulated in the lung mast cells and serum of asthmatic patients [122]

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