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Funding This work was supported by 1R56DK123079-01, 1R01DK123079-01, and 1R01CA240818-01A1 from the NIH, W81XWH-20-1-0625 from the DoD, a Start-up Fund and a SUNY Central Award from Stony Brook University, and a Pilot Project Grant from the Department of Medicine at Stony Brook University to W.L., as well as the National Natural Science Foundation of China (81270540 and 81670585) to Z.L