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SAM (New England Biolabs, #B9003S) was added at a concentration of 320 M, and all the conditions were treated with the same amount of solvent (50 M of H 2 SO 4 and 0.1% ethanol)

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Another important neural circuit is the dopaminergic system

Serine and glycine also charge the folate pool with one-carbon units, including N 10 -formyl-THF, that are ultimately used to produce nucleotides, methionine, and S-adenosylmethionine, the latter of which is the major methyl donor for methyltransferase reactions including those of DNA and histones [62, 63]