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Given that p53 is a protein sensitive to redox changes, it has been hypothesized that the prooxidant environment induced by piperlongumine promotes functional recovery of mutant p53 via protein glutathionylation, ultimately resulting in the apoptosis of human cancer cell lines

Demyelination regulates the circadian transcription factor BMAL1 to signal adult neural stem cells to initiate oligodendrogenesis

These changes markedly reduce its affinity for the insulin-like growth factor-binding proteins (IGFBPs) while retaining agonist activity at the IGF-1 receptor, characteristics that make it a useful reference ligand in growth-factor biology

Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on kras-mutant colorectal cancer