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Response: As we stated in the proposed rule, we are not considering whether to recategorize provisional codes as permanent in this rulemaking for CY 2025 because we intend to conduct a comprehensive analysis of all such provisional codes, which we expect to address in future rulemaking

While emerging evidence establishes ferroptosis as a pivotal mediator of SLE nephritis (LN) pathogenesislinking iron dyshomeostasis, immune cell dysfunction, and renal injuryand identifies GPX4 as a key regulatory checkpoint, several critical, insufficiently addressed research gaps persist

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