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UW228 shows partial sensitivity to SMO inhibitors and transient suppression of GLI1, with resistance mechanisms involving SUFU downregulation or GLI2 amplification

A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents

Animal studies have shown some teratogenic potentialis, so its not recommended during the first trimester of pregnancy

Similar to other cancers, dysregulation of cell cycle proteins is common in MM, resulting in aberrant cycles of cell division that contribute to pathogenesis