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Am J Physiol Cell Physiol (2006) 290(3):C91724.10.1152/ajpcell.00401.2005 57 LotzeMTTraceyKJ

These treatments produced significant atrophy of the prostate and related molecular changes were similar to our in vitro observations

In vivo studies have shown that the combination of ASP and cisplatin can significantly inhibit the growth of transplanted tumors, while having no obvious toxicity to normal tissues and organs, showing a good safety profile (184)