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The analogy holds for the treatment of neurodegenerative diseases

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Taken together, these data confirm that the activity of UCK2 to restore UMP levels is the driving force behind increased PGC1mTOR-linked mitochondrial biogenesis to resolve pyrimidine stress when cells are treated with 5FU

Last but not least, chronic low-grade inflammation is a common condition in T2DM, resulting from diabetes itself as well as from its comorbidities, which has an interdependent relationship with OS [150] and is involved in the pathogenesis of diabetes mellitus-associated ED [151]