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There has even been speculation that people who naturally produce less NAD+ may be more likely to develop substance abuse disorders

Short-term clinical trial data from the Metabolic Pharmaceuticals program did not reveal serious adverse events at the doses tested orally

It is important to note that phentermine does not currently hold a UK marketing authorisation, and there is no MHRA-approved Summary of Product Characteristics (SmPC) for phentermine available on the Electronic Medicines Compendium (EMC)

Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71