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Another study showed the significant activation of ABL kinase in liver samples of ALD patients, as well as in the liver tissues of NIAAA model mice

In oxidative stress responses, Nrf2 undergoes phosphorylation and decouples from Kelch-like ECH-associated protein 1, subsequently entering the cell nucleus to participate in gene transcription, where it can activate the transcription of various antioxidant factors (including heme oxygenase 1, N-acetyl-L-tyrosine oxidoreductase and glutathione S-transferase) (18)

*Correspondence: Jianbo Wang [email protected] Zhao [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers