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Collectively, these findings establish adipocyte Ssu72 as a critical regulator of obesogenic adipogenesis and WAT remodeling, and highlight it as a promising therapeutic target for obesity

[20] The median age was 38.4 years

The researchers note that many steps must be completed before any clinical translation is possible, including developing built-in off switches to safely and reliably remove or deactivate the engineered bacteria after they are no longer needed

239 , 240 , 241 Several underlying mechanisms have been suggested and described, for example, the decrease in lowgrade chronic inflammation, modulation of cytokine microenvironment, restoration of the antioxidant mechanisms, improvement in immune defense against pathogens, increase in telomerase length and activity, modulation of cytokine signaling, and increase in autophagyinduced mitochondrial functions