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This may be in part due to Y box binding protein 1 (YBX1), which has a dual role in SGs and EVs [31,32,33]

Thus far, approximately 40 companies worldwide, including Codiak Biosciences, Evox Therapeutics, Tavec Pharmaceuticals, Carmine Therapeutics, Anjarium, and Micromedmark Biotech, have developed exosome-based therapies, which are expected to provide cost-effective and more accurate targeted therapies in the clinic ( However, challenges, such as large-scale production, purity, and batch homogeneity of exosomes, still limit their clinical application

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Post hoc multiple comparisons were made using the Tukey-Kramer test