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To our knowledge, this is the first study to perform transcriptomic profiling on metformin treated SW837 rectal cancer cells, and supports a previous study in colon cancer cells, demonstrating metformin-induced alteration of genes involved in reactive oxygen species production, cell cycle, programmed cell death and energy metabolism pathways (68)

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Influence of CYP2C9 Polymorphisms, Demographic Factors and Concomitant Drug Therapy on Warfarin Metabolism and Maintenance Dose