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The biggest impact of increasing flavanols, was seen in the COSMOS study, in those in the lowest third for dietary intake specifically seeing improvement in aspects of memory that link to the hippocampus, that central area of the brain that degenerates in Alzheimers (24)

a Phillip et al.(200 b c d e FIGURE 2 FIGURE 3 FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 O -demethylated metabolite i.e., 9- O -demethylmitragynine were detected as the prevalent metabolites of mitragynine, in accord with O -demethylmitragynine was the most abundant metabolite produced by CYP2C19, 2D6, and 3A4, while 9- O -demethyl-16-carboxymitragynine was the least prevalent metabolite hydrolyzed by 2C19

So you mentioned breathing before, and oxygen is really important to humans, but one of the counterintuitive things that I learned from you is that carbon dioxide can actually be a good thing when it comes to healthy breathing

Molecules 27 , 3879 (2022)