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A specific example is the nickel silicate nanoplatforms (LNS NPs), which can generate sufficient superoxide radicals under 660 nm laser irradiation, even inducing apoptosis in tumor cells in severely hypoxic environments, thereby enhancing the effectiveness of PDT for tumors [176]

Although it has been suggested that Ni 2+ may be complexed with S and N-donors 50 , the tissue concentrations of S are orders of magnitude lower than Ni in the three species studied, and unlikely to be important

RBR domain E3 ligases RBR E3 ligases are characterized by a RING-HECT hybrid pattern (Wang et al

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